Development of standardized culture, transplantation and banking of RPE cells for treatment of age-related macular degeneration (AMD)

Czech Republic (CZ)

Project facts

Project promoter:
Institute of Animal Physiology and Genetics CAS(CZ)
Project Number:
CZ-RESEARCH-0006
Status:
In implementation
Initial project cost:
€1,554,030
Donor Project Partners:
University of Oslo(NO)
Other Project Partners
Institute of Macromolecular Chemistry CAS(CZ)
University Hospital Královské Vinohrady(CZ)
Programme:
Research

More information

Description

The project aims to develop a standardized, safe and efficient method for curing dry age-related macular degeneration (AMD) - the most frequent cause of visual impairment that currently lacks treatment. The work will bring promising retina pigment epithelial (RPE) cell research to a clinical trial using patient-derived stem cell therapy. The Specific aims are focused at: 1) isolation, cultivation and optimization of human RPE cells, primary hRPEs and induced pluripotent stem cell (iPSC)-derived RPEs; 2) preparation of nanofibrous scaffold; 3) transplantation of hRPE-covered scaffolds in the subretinal space; 4) non-invasive (OCT, mfERG) and end-stage cell and tissue characterization (IHC, tEM); 5) establishment of good manufacturing practice (GMP) protocols and clinical-grade cell banking.

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