3D yeast colony genomics: A model for cancer progression and development of drug resistance in biofilms
The Czech teams behind this project have shown that yeast colonies behave as primitive multicellular organisms composed of differentiated cell types. Recent findings revealed metabolic parallels between differentiated yeast colonies and tumour-affected organisms as well as defence strategies in biofilm colonies. The main aim of the project is to use next-generation DNA/RNA sequencing methodology provided by the Norwegian partner to identify novel molecular mechanisms involved in the development of yeast cells within both colony types. We anticipate that knowledge gained in this way and published in international scientific journals will find applications in medicine, providing further insight into tumour physiology and in treatment of mycoses. YEASTSEQ will also initiate new long-term cooperation between Czech and Norwegian teams and significantly expand the knowledge and skills of the participating teams, including PhD students and young researchers.
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