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Description
CoSki intends to implement a collaborative initiative for skin research to improve transdermal drug development pre-clinical evaluation. Given the rising ethical questions and the establishment of new rules regarding the prohibition of animal tests, the need of new and efficient in vitro skin mimetic models become essential for pharmaceutical, cosmetic, and toxicological purposes.
CoSki will promote technical cooperation and knowledge exchange between both research groups, also involving an internship a workshop and a seminar. With this bilateral initiative, different skin mimicking models
Summary of the results
CoSki launched a collaborative initiative to advance skin research between UiT The Arctic University of Norway (UiT) and REQUIMTE, Porto, Portugal (PT), focusing on improving the preclinical evaluation of transdermal drug development. Transdermal drug delivery is an emerging approach in pharmaceuticals; however, the skin acts as a significant barrier to drug absorption, necessitating a deeper understanding of how active pharmaceutical ingredients penetrate and diffuse through the skin. With increasing ethical concerns and evolving regulations banning animal testing, the demand for innovative and effective in vitro skin models has become crucial for pharmaceutical, cosmetic, and toxicological applications.
Through CoSki, technical cooperation and knowledge exchange were fostered between the two research groups, engaging both researchers and PhD students. This bilateral initiative facilitated the comparison and evaluation of different skin-mimicking models developed at each institution against standard methods, using dermal formulations based on nanoparticles and hydrogels. Key outcomes included contributions to the systematic development of new skin formulations, enhancement of the CoSki team’s technical expertise, and the establishment of a long-term collaboration between the partners, paving the way for future joint research applications.