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Description
The project aims to develop early diagnostic biomarkers of Alzheimer disease (AD) by validating a series of new biomarkers in serum and cerebrospinal fluid (CSF) in participants from the Czech Brain Aging Study (CBAS).This Czech–Norwegian joint project will involve researchers from CBAS - Czech team with a unique clinical cohort and a top Norwegian research team specialized in mitophagy research. We aim to:
1.)Determine changes of designated mitophagy proteins in serum and CSF of AD individuals compared to non-AD and cognitively normal controls;
2.)Determine the relation to demographics, cognitive status and standard AD biomarkers;
3.)Verify the findings from CBAS on induced pluripotent stem cells and animal models;
4.)Validate specific mitophagy proteins as early diagnostic marker of AD.