Validation of specific mitophagy biomarkers across Alzheimer''s disease continuum

Czech Republic (CZ)

Project facts

Project promoter:
Charles University(CZ)
Project Number:
CZ-RESEARCH-0021
Status:
In implementation
Initial project cost:
€1,403,616
Donor Project Partners:
University of Oslo(NO)
Programme:
Research

More information

Description

The project aims to develop early diagnostic biomarkers of Alzheimer disease (AD) by validating a series of new biomarkers in serum and cerebrospinal fluid (CSF) in participants from the Czech Brain Aging Study (CBAS).This Czech–Norwegian joint project will involve researchers from CBAS - Czech team with a unique clinical cohort and a top Norwegian research team specialized in mitophagy research. We aim to:

1.)Determine changes of designated mitophagy proteins in serum and CSF of AD individuals compared to non-AD and cognitively normal controls;

2.)Determine the relation to demographics, cognitive status and standard AD biomarkers;

3.)Verify the findings from CBAS on induced pluripotent stem cells and animal models;

4.)Validate specific mitophagy proteins as early diagnostic marker of AD.

Information on the projects funded by the EEA and Norway Grants is provided by the Programme and Fund Operators in the Beneficiary States, who are responsible for the completeness and accuracy of this information.