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Description
Hepatitis B and C viruses infect the human liver, triggering persistent inflammation and eventually generating a form of cancer which is the second leading cause of cancer-related mortality worldwide. The main objective of the project is production in premiere of novel antigens with improved properties. In this context, our project proposal aims to: a) build upon our experience and knowledge accumulated in our previous research collaboration on Hepatitis B and C viruses (GreenVac project 2014-2017 funded by the EEA Norway-Romania Program) and produce high yields of novel Hepatitis B and C antigens with superior properties based on innovative molecular design; b) take this experience a step forward and establish in premiere an advanced biotechnological platform for production of Hepatitis B and C antigens in algae; c) take advantage of the multiple recombinant protein expression systems and perform a systematic, comparative characterization of the biochemical and functional properties of the new antigens; d) develop institutional networking around innovative plant and microalgae biotechnologies and train human resources in protein science in applied research in Romania and Norway.