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Description
Through the international cooperation between the Czech Republic and Norway in applied research the project will create conditions for strengthening the development of knowledge based on the research results in biomedicine. The aim of the project is the development of compounds for the treatment of Alzheimer´s disease (AD). The project will include an approaches of personalized medicine during the development process in the way that novel compounds will be tested in a disease in a dish (DiD) model derived from AD patients.
Summary of project results
The TARIMAD project aimed to address the urgent need for effective treatments for Alzheimer''s disease (AD). The lack of disease-modifying drugs and the growing prevalence of AD make it a significant public health concern. The project approach was to develope compounds for personalised treatment of AD.
The project identified promising drug candidates for AD treatment, created a method for identifying individuals at genetic risk for AD, gathered data on the nature of AD, including insights into familial AD, and patented compounds available to the private sector for further drug development.
The project:
- Developed and characterized potential new drugs against AD.
- Evaluated drug properties and side effects in laboratory animals.
- Patented promising compounds for further development by the private sector.
- Developed a method for identifying a genetic risk factor for AD.
- Explored the development of a "disease-in-a-dish" model from patient-derived cells.
- Investigated the nature of AD in pairs of patients (mother and daughter).
The project''s potential beneficiaries include patients with Alzheimer''s disease, their families, healthcare providers, the pharmaceutical industry and researchers studying AD.
Summary of bilateral results
The bilateral collaboration has resulted in mutual research outputs, including joint papers and intellectual property developed in partnership with the donor project partner. This fruitful cooperation facilitated rapid research progress and established a foundation for future partnerships through additional grant projects.